In this article, I focus on the impact on modern Western thinking, ideas, and engagement with the world of the loss of the assumption of a creator, or an intelligent ordering agent, in conjunction with the emphasis on detail in preference to the whole in modern thought. I begin by discussing some of the critical dynamics contributed by Jerusalem, Athens, and Rome to the concept of Europe in an attempt to identify the source of the energy and vitality arising from this synthesis. I particularly look at the synthesis of Jerusalem and Athens, specifically how each influenced the other and where the potential for synergy arose. This Western synthesis no longer operates in Europe and the West.